diff --git a/nixos/doc/manual/release-notes/rl-2505.section.md b/nixos/doc/manual/release-notes/rl-2505.section.md
index 31d1777d3014..d55b5bfd42a7 100644
--- a/nixos/doc/manual/release-notes/rl-2505.section.md
+++ b/nixos/doc/manual/release-notes/rl-2505.section.md
@@ -28,6 +28,8 @@
     After you run ALTER EXTENSION, you must run [this SQL script](https://github.com/timescale/timescaledb-extras/blob/master/utils/2.15.X-fix_hypertable_foreign_keys.sql). For more details, see the following pull requests [#6797](https://github.com/timescale/timescaledb/pull/6797).
     PostgreSQL 13 is no longer supported in TimescaleDB v2.16.
 
+- Support for CUDA 10 has been dropped, as announced in the 24.11 release notes.
+
 - `kanata` was updated to v1.7.0, which introduces several breaking changes.
   See the release notes of
   [v1.7.0](https://github.com/jtroo/kanata/releases/tag/v1.7.0)
diff --git a/pkgs/applications/science/math/caffe/default.nix b/pkgs/applications/science/math/caffe/default.nix
index f82cef9d881c..65e039991b91 100644
--- a/pkgs/applications/science/math/caffe/default.nix
+++ b/pkgs/applications/science/math/caffe/default.nix
@@ -14,23 +14,11 @@
 , Accelerate, CoreGraphics, CoreVideo
 , lmdbSupport ? true, lmdb
 , leveldbSupport ? true, leveldb, snappy
-, cudaSupport ? config.cudaSupport, cudaPackages ? { }
-, cudnnSupport ? cudaSupport
-, ncclSupport ? false
 , pythonSupport ? false, python ? null, numpy ? null
 , substituteAll
 }:
 
 let
-  inherit (cudaPackages) backendStdenv cudatoolkit nccl;
-  # The default for cudatoolkit 10.1 is CUDNN 8.0.5, the last version to support CUDA 10.1.
-  # However, this caffe does not build with CUDNN 8.x, so we use CUDNN 7.6.5 instead.
-  # Earlier versions of cudatoolkit use pre-8.x CUDNN, so we use the default.
-  hasCudnn =
-    if lib.versionOlder cudatoolkit.version "10.1"
-    then cudaPackages ? cudnn
-    else cudaPackages ? cudnn_7_6;
-
   toggle = bool: if bool then "ON" else "OFF";
 
   test_model_weights = fetchurl {
@@ -57,20 +45,12 @@ stdenv.mkDerivation rec {
     # boost_python expects
     [ (if pythonSupport then "-Dpython_version=${python.pythonVersion}" else "-DBUILD_python=OFF")
       "-DBLAS=open"
-    ] ++ (if cudaSupport then [
-           "-DCUDA_ARCH_NAME=All"
-           "-DCUDA_HOST_COMPILER=${backendStdenv.cc}/bin/cc"
-         ] else [ "-DCPU_ONLY=ON" ])
-      ++ ["-DUSE_NCCL=${toggle ncclSupport}"]
-      ++ ["-DUSE_LEVELDB=${toggle leveldbSupport}"]
+      "-DCPU_ONLY=ON"
+    ] ++ ["-DUSE_LEVELDB=${toggle leveldbSupport}"]
       ++ ["-DUSE_LMDB=${toggle lmdbSupport}"];
 
   buildInputs = [ boost gflags glog protobuf hdf5-cpp opencv4 blas ]
-                ++ lib.optional cudaSupport cudatoolkit
-                ++ lib.optional (lib.versionOlder cudatoolkit.version "10.1" && hasCudnn) cudaPackages.cudnn
-                ++ lib.optional (lib.versionAtLeast cudatoolkit.version "10.1" && hasCudnn) cudaPackages.cudnn_7_6
                 ++ lib.optional lmdbSupport lmdb
-                ++ lib.optional ncclSupport nccl
                 ++ lib.optionals leveldbSupport [ leveldb snappy ]
                 ++ lib.optionals pythonSupport [ python numpy ]
                 ++ lib.optionals stdenv.hostPlatform.isDarwin [ Accelerate CoreGraphics CoreVideo ]
@@ -105,9 +85,6 @@ stdenv.mkDerivation rec {
     substituteInPlace src/caffe/util/io.cpp --replace \
       'SetTotalBytesLimit(kProtoReadBytesLimit, 536870912)' \
       'SetTotalBytesLimit(kProtoReadBytesLimit)'
-  '' + lib.optionalString (cudaSupport && lib.versionAtLeast cudatoolkit.version "9.0") ''
-    # CUDA 9.0 doesn't support sm_20
-    sed -i 's,20 21(20) ,,' cmake/Cuda.cmake
   '';
 
   preConfigure = lib.optionalString pythonSupport ''
@@ -150,10 +127,7 @@ stdenv.mkDerivation rec {
     maintainers = [ ];
     broken =
       (pythonSupport && (python.isPy310))
-      || cudaSupport
       || !(leveldbSupport -> (leveldb != null && snappy != null))
-      || !(cudnnSupport -> (hasCudnn && cudaSupport))
-      || !(ncclSupport -> (cudaSupport && !nccl.meta.unsupported))
       || !(pythonSupport -> (python != null && numpy != null))
     ;
     license = licenses.bsd2;
diff --git a/pkgs/by-name/dc/dcgm/dynamic-libs.patch b/pkgs/by-name/dc/dcgm/dynamic-libs.patch
new file mode 100644
index 000000000000..fcc544c75bed
--- /dev/null
+++ b/pkgs/by-name/dc/dcgm/dynamic-libs.patch
@@ -0,0 +1,40 @@
+diff --git a/cmake/FindJsoncpp.cmake b/cmake/FindJsoncpp.cmake
+index abedf7bb85..d7a52f5c7b 100644
+--- a/cmake/FindJsoncpp.cmake
++++ b/cmake/FindJsoncpp.cmake
+@@ -16,8 +16,8 @@
+ 
+ if (NOT TARGET JsonCpp::JsonCpp)
+     find_package(jsoncpp REQUIRED CONFIG)
+-    set(JSONCPP_STATIC_LIBS jsoncpp_static)
+-    set(JSONCPP_INCLUDE_PATH $<TARGET_PROPERTY:jsoncpp_static,INTERFACE_INCLUDE_DIRECTORIES>)
++    set(JSONCPP_STATIC_LIBS jsoncpp)
++    set(JSONCPP_INCLUDE_PATH $<TARGET_PROPERTY:jsoncpp,INTERFACE_INCLUDE_DIRECTORIES>)
+ endif()
+ # set(Jsoncpp_PATH_PREFIXES /usr/local "${Jsoncpp_ROOT}" "$ENV{HOME}")
+ # foreach(prefix ${Jsoncpp_PATH_PREFIXES})
+diff --git a/cmake/FindLibevent.cmake b/cmake/FindLibevent.cmake
+index 354d6f9b99..38aca9534e 100644
+--- a/cmake/FindLibevent.cmake
++++ b/cmake/FindLibevent.cmake
+@@ -26,16 +26,12 @@
+ endforeach()
+ 
+ find_path(LIBEVENT_INCLUDE_DIR evhttp.h event.h PATHS ${Libevent_INCLUDE_PATHS})
+-find_library(LIBEVENT_STATIC_LIB NAMES libevent.a libevent_core.a libevent_extra.a PATHS ${Libevent_LIB_PATHS})
+-find_library(LIBEVENT_PTHREAD_STATIC_LIB NAMES libevent_pthreads.a PATHS ${Libevent_LIB_PATHS})
++find_library(LIBEVENT_STATIC_LIB NAMES libevent.so libevent_core.so libevent_extra.so PATHS ${Libevent_LIB_PATHS})
++find_library(LIBEVENT_PTHREAD_STATIC_LIB NAMES libevent_pthreads.so PATHS ${Libevent_LIB_PATHS})
+ 
+-if (LIBEVENT_INCLUDE_DIR AND LIBEVENT_STATIC_LIB AND LIBEVENT_PTHREAD_STATIC_LIB)
++if (LIBEVENT_INCLUDE_DIR AND LIBEVENT_STATIC_LIB)
+     set(Libevent_FOUND TRUE)
+-    add_library(libevent_event_static STATIC IMPORTED)
+-    set_target_properties(libevent_event_static PROPERTIES IMPORTED_LOCATION ${LIBEVENT_STATIC_LIB})
+-    add_library(libevent_event_pthread STATIC IMPORTED)
+-    set_target_properties(libevent_event_pthread PROPERTIES IMPORTED_LOCATION ${LIBEVENT_PTHREAD_STATIC_LIB})
+-    set(LIBEVENT_STATIC_LIBS libevent_event_static libevent_event_pthread)
++    set(LIBEVENT_STATIC_LIBS ${LIBEVENT_STATIC_LIB} ${LIBEVENT_PTHREAD_STATIC_LIB})
+ else ()
+     set(Libevent_FOUND FALSE)
+ endif ()
diff --git a/pkgs/by-name/dc/dcgm/fix-includes.patch b/pkgs/by-name/dc/dcgm/fix-includes.patch
new file mode 100644
index 000000000000..2f15ddca1f7e
--- /dev/null
+++ b/pkgs/by-name/dc/dcgm/fix-includes.patch
@@ -0,0 +1,110 @@
+diff --git a/common/CudaWorker/DcgmDgemm.cpp b/common/CudaWorker/DcgmDgemm.cpp
+index 8d33a3256e..6b3284258d 100644
+--- a/common/CudaWorker/DcgmDgemm.cpp
++++ b/common/CudaWorker/DcgmDgemm.cpp
+@@ -17,6 +17,7 @@
+ 
+ #include <exception>
+ #include <stdexcept>
++#include <cinttypes>
+ 
+ #define CU_CHK(op)                                               \
+     if (auto const status = op; status != CUBLAS_STATUS_SUCCESS) \
+@@ -122,4 +123,4 @@
+     return CUBLAS_STATUS_SUCCESS;
+ }
+ 
+-} // namespace DcgmNs
+\ No newline at end of file
++} // namespace DcgmNs
+diff --git a/common/DcgmError.h b/common/DcgmError.h
+index 8638cdceb1..e8d817c0d4 100644
+--- a/common/DcgmError.h
++++ b/common/DcgmError.h
+@@ -17,6 +17,7 @@
+ 
+ #include <sstream>
+ #include <string>
++#include <cinttypes>
+ 
+ #include <dcgm_agent.h>
+ #include <dcgm_errors.h>
+diff --git a/common/DcgmStringHelpers.cpp b/common/DcgmStringHelpers.cpp
+index b41917e3b7..1fe63980c7 100644
+--- a/common/DcgmStringHelpers.cpp
++++ b/common/DcgmStringHelpers.cpp
+@@ -17,6 +17,7 @@
+ 
+ #include <cstring>
+ #include <string>
++#include <algorithm>
+ 
+ /*****************************************************************************/
+ void dcgmTokenizeString(const std::string &src, const std::string &delimiter, std::vector<std::string> &tokens)
+diff --git a/dcgmi/CommandOutputController.cpp b/dcgmi/CommandOutputController.cpp
+index 5057205564..8520171efa 100644
+--- a/dcgmi/CommandOutputController.cpp
++++ b/dcgmi/CommandOutputController.cpp
+@@ -24,6 +24,7 @@
+ #include "dcgm_agent.h"
+ #include <DcgmStringHelpers.h>
+ #include <algorithm>
++#include <functional>
+ #include <cstdarg>
+ #include <iostream>
+ #include <string>
+diff --git a/dcgmi/Diag.h b/dcgmi/Diag.h
+index a326f7b949..563fb3c9c0 100755
+--- a/dcgmi/Diag.h
++++ b/dcgmi/Diag.h
+@@ -24,6 +24,7 @@
+ #define DIAG_H_
+ 
+ #include <optional>
++#include <functional>
+ 
+ #include "Command.h"
+ #include "CommandOutputController.h"
+diff --git a/hostengine/src/HostEngineOutput.cpp b/hostengine/src/HostEngineOutput.cpp
+index 23c6ca9f54..798b83b3e4 100644
+--- a/hostengine/src/HostEngineOutput.cpp
++++ b/hostengine/src/HostEngineOutput.cpp
+@@ -20,6 +20,7 @@
+ #include <iostream>
+ #include <limits>
+ #include <string_view>
++#include <unordered_map>
+ 
+ namespace
+ {
+@@ -365,4 +366,4 @@
+         }
+     }
+     os << std::endl;
+-}
+\ No newline at end of file
++}
+diff --git a/nvvs/src/NvvsCommon.cpp b/nvvs/src/NvvsCommon.cpp
+index 8f7888649b..1604d9dabe 100644
+--- a/nvvs/src/NvvsCommon.cpp
++++ b/nvvs/src/NvvsCommon.cpp
+@@ -15,6 +15,7 @@
+  */
+ #include <sstream>
+ #include <stdexcept>
++#include <algorithm>
+ #include <sys/stat.h>
+ #include <sys/types.h>
+ 
+diff --git a/sdk/nvidia/nvml/nvml_loader/nvml_loader.cpp b/sdk/nvidia/nvml/nvml_loader/nvml_loader.cpp
+index 9eebeaf1c4..6e21201229 100644
+--- a/sdk/nvidia/nvml/nvml_loader/nvml_loader.cpp
++++ b/sdk/nvidia/nvml/nvml_loader/nvml_loader.cpp
+@@ -20,6 +20,7 @@
+ 
+ #include <atomic>
+ #include <mutex>
++#include <cstdlib>
+ 
+ static void *g_nvmlLib                                     = 0;
+ static std::atomic_uint32_t g_nvmlStaticLibResetHooksCount = 1;
diff --git a/pkgs/by-name/dc/dcgm/package.nix b/pkgs/by-name/dc/dcgm/package.nix
index 7573cb37ec22..e0de192b3daf 100644
--- a/pkgs/by-name/dc/dcgm/package.nix
+++ b/pkgs/by-name/dc/dcgm/package.nix
@@ -1,12 +1,13 @@
 { lib
-, gcc11Stdenv
+, stdenv
 , fetchFromGitHub
 , autoAddDriverRunpath
 , catch2
 , cmake
-, cudaPackages_10_2
+, ninja
 , cudaPackages_11_8
 , cudaPackages_12
+, boost
 , fmt_9
 , git
 , jsoncpp
@@ -16,30 +17,14 @@
 , symlinkJoin
 , tclap_1_4
 , yaml-cpp
-
-, static ? gcc11Stdenv.hostPlatform.isStatic
 }:
 let
-  # DCGM depends on 3 different versions of CUDA at the same time.
-  # The runtime closure, thankfully, is quite small because most things
-  # are statically linked.
-  cudaPackageSetByVersion = [
-    {
-      version = "10";
-      # Nixpkgs cudaPackages_10 doesn't have redist packages broken out.
-      pkgSet = [
-        cudaPackages_10_2.cudatoolkit
-        cudaPackages_10_2.cudatoolkit.lib
-      ];
-    }
-    {
-      version = "11";
-      pkgSet = getCudaPackages cudaPackages_11_8;
-    }
-    {
-      version = "12";
-      pkgSet = getCudaPackages cudaPackages_12;
-    }
+  # DCGM depends on 2 different versions of CUDA at the same time.
+  # The runtime closure, thankfully, is quite small as it does not
+  # include the CUDA libraries.
+  cudaPackageSets = [
+    cudaPackages_11_8
+    cudaPackages_12
   ];
 
   # Select needed redist packages from cudaPackages
@@ -54,44 +39,40 @@ let
     libcurand
   ];
 
-  # Builds CMake code to add CUDA paths for include and lib.
-  mkAppendCudaPaths = { version, pkgSet }:
+  # Builds CMake flags to add CUDA paths for include and lib.
+  mkCudaFlags = cudaPackages:
     let
+      version = cudaPackages.cudaMajorVersion;
       # The DCGM CMake assumes that the folder containing cuda.h contains all headers, so we must
       # combine everything together for headers to work.
-      # It would be more convenient to use symlinkJoin on *just* the include subdirectories
-      # of each package, but not all of them have an include directory and making that work
-      # is more effort than it's worth for this temporary, build-time package.
-      combined = symlinkJoin {
-        name = "cuda-combined-${version}";
-        paths = pkgSet;
+      headers = symlinkJoin {
+        name = "cuda-headers-combined-${version}";
+        paths = lib.map (pkg: "${lib.getInclude pkg}/include") (getCudaPackages cudaPackages);
       };
-      # The combined package above breaks the build for some reason so we just configure
-      # each package's library path.
-      libs = lib.concatMapStringsSep " " (x: ''"${x}/lib"'') pkgSet;
-    in ''
-      list(APPEND Cuda${version}_INCLUDE_PATHS "${combined}/include")
-      list(APPEND Cuda${version}_LIB_PATHS ${libs})
-    '';
-
-# gcc11 is required by DCGM's very particular build system
-# C.f. https://github.com/NVIDIA/DCGM/blob/7e1012302679e4bb7496483b32dcffb56e528c92/dcgmbuild/build.sh#L22
-in gcc11Stdenv.mkDerivation rec {
+    in [
+      (lib.cmakeFeature "CUDA${version}_INCLUDE_DIR" "${headers}")
+      (lib.cmakeFeature "CUDA${version}_LIBS" "${cudaPackages.cuda_cudart.stubs}/lib/stubs/libcuda.so")
+      (lib.cmakeFeature "CUDA${version}_STATIC_LIBS" "${lib.getLib cudaPackages.cuda_cudart}/lib/libcudart.so")
+      (lib.cmakeFeature "CUDA${version}_STATIC_CUBLAS_LIBS" (lib.concatStringsSep ";" [
+        "${lib.getLib cudaPackages.libcublas}/lib/libcublas.so"
+        "${lib.getLib cudaPackages.libcublas}/lib/libcublasLt.so"
+      ]))
+    ];
+in stdenv.mkDerivation rec {
   pname = "dcgm";
-  version = "3.3.5"; # N.B: If you change this, be sure prometheus-dcgm-exporter supports this version.
+  version = "3.3.9"; # N.B: If you change this, be sure prometheus-dcgm-exporter supports this version.
 
   src = fetchFromGitHub {
     owner = "NVIDIA";
     repo = "DCGM";
     rev = "refs/tags/v${version}";
-    hash = "sha256-n/uWvgvxAGfr1X51XgtHfFGDOO5AMBSV5UWQQpsylpg=";
+    hash = "sha256-PysxuN5WT7GB0oOvT5ezYeOau6AMVDDWE5HOAcmqw/Y=";
   };
 
-  # Add our paths to the CUDA paths so FindCuda.cmake can find them.
-  EXTRA_CUDA_PATHS = lib.concatMapStringsSep "\n" mkAppendCudaPaths cudaPackageSetByVersion;
-  prePatch = ''
-    echo "$EXTRA_CUDA_PATHS"$'\n'"$(cat cmake/FindCuda.cmake)" > cmake/FindCuda.cmake
-  '';
+  patches = [
+    ./fix-includes.patch
+    ./dynamic-libs.patch
+  ];
 
   hardeningDisable = [ "all" ];
 
@@ -104,26 +85,55 @@ in gcc11Stdenv.mkDerivation rec {
     autoAddDriverRunpath
 
     cmake
+    ninja
     git
     python3
   ];
 
   buildInputs = [
     # Header-only
+    boost
     catch2
     plog.dev
     tclap_1_4
 
-    # Dependencies that can be either static or dynamic.
-    (fmt_9.override { enableShared = !static; }) # DCGM's build uses the static outputs regardless of enableShared
-    (yaml-cpp.override { inherit static; stdenv = gcc11Stdenv; })
-
-    # TODO: Dependencies that DCGM's CMake hard-codes to be static-only.
-    (jsoncpp.override { enableStatic = true; })
-    (libevent.override { sslSupport = false; static = true; })
+    fmt_9
+    yaml-cpp
+    jsoncpp
+    libevent
   ];
 
-  disallowedReferences = lib.concatMap (x: x.pkgSet) cudaPackageSetByVersion;
+  # Add our paths to the CMake flags so FindCuda.cmake can find them.
+  cmakeFlags = lib.concatMap mkCudaFlags cudaPackageSets;
+
+  # Lots of dodgy C++.
+  env.NIX_CFLAGS_COMPILE = "-Wno-error";
+
+  doCheck = true;
+
+  checkPhase = ''
+    runHook preCheck
+
+    ctest -j $NIX_BUILD_CORES --output-on-failure --exclude-regex ${
+      lib.escapeShellArg (
+        lib.concatMapStringsSep "|" (test: "^${lib.escapeRegex test}$") [
+          "DcgmModuleSysmon Watches"
+          "DcgmModuleSysmon maxSampleAge"
+          "DcgmModuleSysmon::CalculateCoreUtilization"
+          "DcgmModuleSysmon::ParseProcStatCpuLine"
+          "DcgmModuleSysmon::ParseThermalFileContentsAndStore"
+          "DcgmModuleSysmon::PopulateTemperatureFileMap"
+          "DcgmModuleSysmon::ReadCoreSpeed"
+          "DcgmModuleSysmon::ReadTemperature"
+          "Sysmon: initialize module"
+        ]
+      )
+    }
+
+    runHook postCheck
+  '';
+
+  disallowedReferences = lib.concatMap getCudaPackages cudaPackageSets;
 
   meta = with lib; {
     description = "Data Center GPU Manager (DCGM) is a daemon that allows users to monitor NVIDIA data-center GPUs";
diff --git a/pkgs/by-name/pr/prometheus-dcgm-exporter/package.nix b/pkgs/by-name/pr/prometheus-dcgm-exporter/package.nix
index 05b210ac2efe..df9ac3ef4d41 100644
--- a/pkgs/by-name/pr/prometheus-dcgm-exporter/package.nix
+++ b/pkgs/by-name/pr/prometheus-dcgm-exporter/package.nix
@@ -9,13 +9,13 @@ buildGoModule rec {
 
   # The first portion of this version string corresponds to a compatible DCGM
   # version.
-  version = "3.3.5-3.4.0"; # N.B: If you change this, update dcgm as well to the matching version.
+  version = "3.3.9-3.6.1"; # N.B: If you change this, update dcgm as well to the matching version.
 
   src = fetchFromGitHub {
     owner = "NVIDIA";
     repo = pname;
     rev = "refs/tags/${version}";
-    hash = "sha256-IOVPEK+9ogBZJYns2pTyJwHUBMN8JqG1THTJPvpCwdo=";
+    hash = "sha256-BAMN2yuIW5FcHY3o9MUIMgPnTEFFRCbqhoAkcaZDxcM=";
   };
 
   CGO_LDFLAGS = "-ldcgm";
@@ -28,7 +28,7 @@ buildGoModule rec {
   # symbols are available on startup.
   hardeningDisable = [ "bindnow" ];
 
-  vendorHash = "sha256-urKa0O8QZnM8cWjPcGVhoAWhx6fCdMmhRX0JOriRaig=";
+  vendorHash = "sha256-b7GyPsmSGHx7hK0pDa88FKA+ZKJES2cdAGjT2aAfX/A=";
 
   nativeBuildInputs = [
     autoAddDriverRunpath
diff --git a/pkgs/development/cuda-modules/cudatoolkit/default.nix b/pkgs/development/cuda-modules/cudatoolkit/default.nix
index f7be0aa9f4fd..71a745174600 100644
--- a/pkgs/development/cuda-modules/cudatoolkit/default.nix
+++ b/pkgs/development/cuda-modules/cudatoolkit/default.nix
@@ -69,26 +69,18 @@ backendStdenv.mkDerivation rec {
     "doc"
   ];
 
-  nativeBuildInputs =
-    [
-      perl
-      makeWrapper
-      rsync
-      addDriverRunpath
-      autoPatchelfHook
-      autoAddDriverRunpath
-      markForCudatoolkitRootHook
-    ]
-    ++ lib.optionals (lib.versionOlder version "11") [ libsForQt5.wrapQtAppsHook ]
-    ++ lib.optionals (lib.versionAtLeast version "11.8") [ qt6Packages.wrapQtAppsHook ];
+  nativeBuildInputs = [
+    perl
+    makeWrapper
+    rsync
+    addDriverRunpath
+    autoPatchelfHook
+    autoAddDriverRunpath
+    markForCudatoolkitRootHook
+  ] ++ lib.optionals (lib.versionAtLeast version "11.8") [ qt6Packages.wrapQtAppsHook ];
   propagatedBuildInputs = [ setupCudaHook ];
   buildInputs =
-    lib.optionals (lib.versionOlder version "11") [
-      libsForQt5.qt5.qtwebengine
-      libglut
-      libGLU
-    ]
-    ++ [
+    [
       # To get $GDK_PIXBUF_MODULE_FILE via setup-hook
       gdk-pixbuf
 
@@ -168,105 +160,58 @@ backendStdenv.mkDerivation rec {
     "${placeholder "out"}/nvvm/lib64"
   ];
 
-  autoPatchelfIgnoreMissingDeps =
-    [
-      # This is the hardware-dependent userspace driver that comes from
-      # nvidia_x11 package. It must be deployed at runtime in
-      # /run/opengl-driver/lib or pointed at by LD_LIBRARY_PATH variable, rather
-      # than pinned in runpath
-      "libcuda.so.1"
+  autoPatchelfIgnoreMissingDeps = [
+    # This is the hardware-dependent userspace driver that comes from
+    # nvidia_x11 package. It must be deployed at runtime in
+    # /run/opengl-driver/lib or pointed at by LD_LIBRARY_PATH variable, rather
+    # than pinned in runpath
+    "libcuda.so.1"
 
-      # The krb5 expression ships libcom_err.so.3 but cudatoolkit asks for the
-      # older
-      # This dependency is asked for by target-linux-x64/CollectX/RedHat/x86_64/libssl.so.10
-      # - do we even want to use nvidia-shipped libssl?
-      "libcom_err.so.2"
-    ]
-    ++ lib.optionals (lib.versionOlder version "10.1") [
-      # For Cuda 10.0, nVidia also shipped a jre implementation which needed
-      # two old versions of ffmpeg which are not available in nixpkgs
-      "libavcodec.so.54"
-      "libavcodec.so.53"
-      "libavformat.so.54"
-      "libavformat.so.53"
-    ];
+    # The krb5 expression ships libcom_err.so.3 but cudatoolkit asks for the
+    # older
+    # This dependency is asked for by target-linux-x64/CollectX/RedHat/x86_64/libssl.so.10
+    # - do we even want to use nvidia-shipped libssl?
+    "libcom_err.so.2"
+  ];
 
-  preFixup =
-    if (lib.versionAtLeast version "10.1" && lib.versionOlder version "11") then
-      ''
-        ${lib.getExe' patchelf "patchelf"} $out/targets/*/lib/libnvrtc.so --add-needed libnvrtc-builtins.so
-      ''
-    else
-      ''
-        ${lib.getExe' patchelf "patchelf"} $out/lib64/libnvrtc.so --add-needed libnvrtc-builtins.so
-      '';
+  preFixup = ''
+    ${lib.getExe' patchelf "patchelf"} $out/lib64/libnvrtc.so --add-needed libnvrtc-builtins.so
+  '';
 
   unpackPhase = ''
     sh $src --keep --noexec
-
-    ${lib.optionalString (lib.versionOlder version "10.1") ''
-      cd pkg/run_files
-      sh cuda-linux*.run --keep --noexec
-      sh cuda-samples*.run --keep --noexec
-      mv pkg ../../$(basename $src)
-      cd ../..
-      rm -rf pkg
-
-      for patch in $runPatches; do
-        sh $patch --keep --noexec
-        mv pkg $(basename $patch)
-      done
-    ''}
   '';
 
   installPhase =
     ''
       runHook preInstall
       mkdir $out
-      ${lib.optionalString (lib.versionOlder version "10.1") ''
-        cd $(basename $src)
-        export PERL5LIB=.
-        perl ./install-linux.pl --prefix="$out"
-        cd ..
-        for patch in $runPatches; do
-          cd $(basename $patch)
-          perl ./install_patch.pl --silent --accept-eula --installdir="$out"
-          cd ..
-        done
-      ''}
-      ${lib.optionalString (lib.versionAtLeast version "10.1" && lib.versionOlder version "11") ''
-        cd pkg/builds/cuda-toolkit
-        mv * $out/
-        rm -f $out/nsight-systems-*/host-linux-x64/libstdc++.so*
-      ''}
-      ${lib.optionalString (lib.versionAtLeast version "11") ''
-        mkdir -p $out/bin $out/lib64 $out/include $doc
-        for dir in pkg/builds/* pkg/builds/cuda_nvcc/nvvm pkg/builds/cuda_cupti/extras/CUPTI; do
-          if [ -d $dir/bin ]; then
-            mv $dir/bin/* $out/bin
-          fi
-          if [ -d $dir/doc ]; then
-            (cd $dir/doc && find . -type d -exec mkdir -p $doc/\{} \;)
-            (cd $dir/doc && find . \( -type f -o -type l \) -exec mv \{} $doc/\{} \;)
-          fi
-          if [ -L $dir/include ] || [ -d $dir/include ]; then
-            (cd $dir/include && find . -type d -exec mkdir -p $out/include/\{} \;)
-            (cd $dir/include && find . \( -type f -o -type l \) -exec mv \{} $out/include/\{} \;)
-          fi
-          if [ -L $dir/lib64 ] || [ -d $dir/lib64 ]; then
-            (cd $dir/lib64 && find . -type d -exec mkdir -p $out/lib64/\{} \;)
-            (cd $dir/lib64 && find . \( -type f -o -type l \) -exec mv \{} $out/lib64/\{} \;)
-          fi
-        done
-        mv pkg/builds/cuda_nvcc/nvvm $out/nvvm
+      mkdir -p $out/bin $out/lib64 $out/include $doc
+      for dir in pkg/builds/* pkg/builds/cuda_nvcc/nvvm pkg/builds/cuda_cupti/extras/CUPTI; do
+        if [ -d $dir/bin ]; then
+          mv $dir/bin/* $out/bin
+        fi
+        if [ -d $dir/doc ]; then
+          (cd $dir/doc && find . -type d -exec mkdir -p $doc/\{} \;)
+          (cd $dir/doc && find . \( -type f -o -type l \) -exec mv \{} $doc/\{} \;)
+        fi
+        if [ -L $dir/include ] || [ -d $dir/include ]; then
+          (cd $dir/include && find . -type d -exec mkdir -p $out/include/\{} \;)
+          (cd $dir/include && find . \( -type f -o -type l \) -exec mv \{} $out/include/\{} \;)
+        fi
+        if [ -L $dir/lib64 ] || [ -d $dir/lib64 ]; then
+          (cd $dir/lib64 && find . -type d -exec mkdir -p $out/lib64/\{} \;)
+          (cd $dir/lib64 && find . \( -type f -o -type l \) -exec mv \{} $out/lib64/\{} \;)
+        fi
+      done
+      mv pkg/builds/cuda_nvcc/nvvm $out/nvvm
 
-        mv pkg/builds/cuda_sanitizer_api $out/cuda_sanitizer_api
-        ln -s $out/cuda_sanitizer_api/compute-sanitizer/compute-sanitizer $out/bin/compute-sanitizer
+      mv pkg/builds/cuda_sanitizer_api $out/cuda_sanitizer_api
+      ln -s $out/cuda_sanitizer_api/compute-sanitizer/compute-sanitizer $out/bin/compute-sanitizer
 
-        mv pkg/builds/nsight_systems/target-linux-x64 $out/target-linux-x64
-        mv pkg/builds/nsight_systems/host-linux-x64 $out/host-linux-x64
-        rm $out/host-linux-x64/libstdc++.so*
-      ''}
+      mv pkg/builds/nsight_systems/target-linux-x64 $out/target-linux-x64
+      mv pkg/builds/nsight_systems/host-linux-x64 $out/host-linux-x64
+      rm $out/host-linux-x64/libstdc++.so*
         ${
           lib.optionalString (lib.versionAtLeast version "11.8" && lib.versionOlder version "12")
             # error: auto-patchelf could not satisfy dependency libtiff.so.5 wanted by /nix/store/.......-cudatoolkit-12.0.1/host-linux-x64/Plugins/imageformats/libqtiff.so
@@ -301,20 +246,10 @@ backendStdenv.mkDerivation rec {
 
       rm -f $out/tools/CUDA_Occupancy_Calculator.xls # FIXME: why?
 
-      ${lib.optionalString (lib.versionOlder version "10.1") ''
-        # let's remove the 32-bit libraries, they confuse the lib64->lib mover
-        rm -rf $out/lib
-      ''}
-
       ${lib.optionalString (lib.versionAtLeast version "12.0") ''
         rm $out/host-linux-x64/libQt6*
       ''}
 
-      # Remove some cruft.
-      ${lib.optionalString (
-        (lib.versionAtLeast version "7.0") && (lib.versionOlder version "10.1")
-      ) "rm $out/bin/uninstall*"}
-
       # Fixup path to samples (needed for cuda 6.5 or else nsight will not find them)
       if [ -d "$out"/cuda-samples ]; then
           mv "$out"/cuda-samples "$out"/samples
@@ -343,19 +278,11 @@ backendStdenv.mkDerivation rec {
 
         # Remove OpenCL libraries as they are provided by ocl-icd and driver.
         rm -f $out/lib64/libOpenCL*
-        ${lib.optionalString (lib.versionAtLeast version "10.1" && (lib.versionOlder version "11")) ''
-          mv $out/lib64 $out/lib
-          mv $out/extras/CUPTI/lib64/libcupti* $out/lib
-        ''}
 
         # nvprof do not find any program to profile if LD_LIBRARY_PATH is not set
         wrapProgram $out/bin/nvprof \
           --prefix LD_LIBRARY_PATH : $out/lib
       ''
-    + lib.optionalString (lib.versionOlder version "8.0") ''
-      # Hack to fix building against recent Glibc/GCC.
-      echo "NIX_CFLAGS_COMPILE+=' -D_FORCE_INLINES'" >> $out/nix-support/setup-hook
-    ''
     # 11.8 includes a broken symlink, include/include, pointing to targets/x86_64-linux/include
     + lib.optionalString (lib.versions.majorMinor version == "11.8") ''
       rm $out/include/include
@@ -365,7 +292,7 @@ backendStdenv.mkDerivation rec {
     '';
 
   postInstall = ''
-    for b in nvvp ${lib.optionalString (lib.versionOlder version "11") "nsight"}; do
+    for b in nvvp; do
       wrapProgram "$out/bin/$b" \
         --set GDK_PIXBUF_MODULE_FILE "$GDK_PIXBUF_MODULE_FILE"
     done
diff --git a/pkgs/development/cuda-modules/cudatoolkit/releases.nix b/pkgs/development/cuda-modules/cudatoolkit/releases.nix
index 05f7b144ec4b..147bf89adf0a 100644
--- a/pkgs/development/cuda-modules/cudatoolkit/releases.nix
+++ b/pkgs/development/cuda-modules/cudatoolkit/releases.nix
@@ -10,24 +10,6 @@
 # }
 # Releases = AttrSet CudaVersion Release
 {
-  "10.0" = {
-    version = "10.0.130";
-    url = "https://developer.nvidia.com/compute/cuda/10.0/Prod/local_installers/cuda_10.0.130_410.48_linux";
-    sha256 = "16p3bv1lwmyqpxil8r951h385sy9asc578afrc7lssa68c71ydcj";
-  };
-
-  "10.1" = {
-    version = "10.1.243";
-    url = "https://developer.download.nvidia.com/compute/cuda/10.1/Prod/local_installers/cuda_10.1.243_418.87.00_linux.run";
-    sha256 = "0caxhlv2bdq863dfp6wj7nad66ml81vasq2ayf11psvq2b12vhp7";
-  };
-
-  "10.2" = {
-    version = "10.2.89";
-    url = "http://developer.download.nvidia.com/compute/cuda/10.2/Prod/local_installers/cuda_10.2.89_440.33.01_linux.run";
-    sha256 = "04fasl9sjkb1jvchvqgaqxprnprcz7a8r52249zp2ijarzyhf3an";
-  };
-
   "11.0" = {
     version = "11.0.3";
     url = "https://developer.download.nvidia.com/compute/cuda/11.0.3/local_installers/cuda_11.0.3_450.51.06_linux.run";
diff --git a/pkgs/development/cuda-modules/cudnn/releases.nix b/pkgs/development/cuda-modules/cudnn/releases.nix
index 2b4afc160abe..586bdecf67c0 100644
--- a/pkgs/development/cuda-modules/cudnn/releases.nix
+++ b/pkgs/development/cuda-modules/cudnn/releases.nix
@@ -96,48 +96,6 @@
     ];
     # x86_64
     linux-x86_64 = [
-      {
-        version = "7.4.2.24";
-        minCudaVersion = "10.0";
-        maxCudaVersion = "10.0";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v7.4.2/cudnn-10.0-linux-x64-v7.4.2.24.tgz";
-        hash = "sha256-Lt/IagK1DRfojEeJVaMy5qHoF05+U6NFi06lH68C2qM=";
-      }
-      {
-        version = "7.6.5.32";
-        minCudaVersion = "10.0";
-        maxCudaVersion = "10.0";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v7.6.5/cudnn-10.0-linux-x64-v7.6.5.32.tgz";
-        hash = "sha256-KDVeOV8LK5OsLIO2E2CzW6bNA3fkTni+GXtrYbS0kro=";
-      }
-      {
-        version = "7.6.5.32";
-        minCudaVersion = "10.1";
-        maxCudaVersion = "10.1";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v7.6.5/cudnn-10.1-linux-x64-v7.6.5.32.tgz";
-        hash = "sha256-fq7IA5osMKsLx1jTA1iHZ2k972v0myJIWiwAvy4TbLM=";
-      }
-      {
-        version = "7.6.5.32";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v7.6.5/cudnn-10.2-linux-x64-v7.6.5.32.tgz";
-        hash = "sha256-YAJn8squ0v1Y6yFLpmnY6jXzlqfRm5SCLms2+fcIjCA='";
-      }
-      {
-        version = "8.0.5.39";
-        minCudaVersion = "10.1";
-        maxCudaVersion = "10.1";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.0.5/cudnn-10.1-linux-x64-v8.0.5.39.tgz";
-        hash = "sha256-kJCElSmIlrM6qVBjo0cfk8NmJ9esAcF9w211xl7qSgA=";
-      }
-      {
-        version = "8.0.5.39";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.0.5/cudnn-10.2-linux-x64-v8.0.5.39.tgz";
-        hash = "sha256-IfhMBcZ78eyFnnfDjM1b8VSWT6HDCPRJlZvkw1bjgvM=";
-      }
       {
         version = "8.0.5.39";
         minCudaVersion = "11.0";
@@ -152,13 +110,6 @@
         url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.0.5/cudnn-11.1-linux-x64-v8.0.5.39.tgz";
         hash = "sha256-HQRr+nk5navMb2yxUHkYdUQ5RC6gyp4Pvs3URvmwDM4=";
       }
-      {
-        version = "8.1.1.33";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.1.1/cudnn-10.2-linux-x64-v8.1.1.33.tgz";
-        hash = "sha256-Kkp7mabpv6aQ6xm7QeSVU/KnpJGls6v8rpAOFmxbbr0=";
-      }
       {
         version = "8.1.1.33";
         minCudaVersion = "11.0";
@@ -166,13 +117,6 @@
         url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.1.1/cudnn-11.2-linux-x64-v8.1.1.33.tgz";
         hash = "sha256-mKh4TpKGLyABjSDCgbMNSgzZUfk2lPZDPM9K6cUCumo=";
       }
-      {
-        version = "8.2.4.15";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.2.4/cudnn-10.2-linux-x64-v8.2.4.15.tgz";
-        hash = "sha256-0jyUoxFaHHcRamwSfZF1+/WfcjNkN08mo0aZB18yIvE=";
-      }
       {
         version = "8.2.4.15";
         minCudaVersion = "11.0";
@@ -180,13 +124,6 @@
         url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.2.4/cudnn-11.4-linux-x64-v8.2.4.15.tgz";
         hash = "sha256-Dl0t+JC5ln76ZhnaQhMQ2XMjVlp58FoajLm3Fluq0Nc=";
       }
-      {
-        version = "8.3.3.40";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.3.3/local_installers/10.2/cudnn-linux-x86_64-8.3.3.40_cuda10.2-archive.tar.xz";
-        hash = "sha256-2FVPKzLmKV1fyPOsJeaPlAWLAYyAHaucFD42gS+JJqs=";
-      }
       {
         version = "8.3.3.40";
         minCudaVersion = "11.0";
@@ -194,13 +131,6 @@
         url = "https://developer.download.nvidia.com/compute/redist/cudnn/v8.3.3/local_installers/11.5/cudnn-linux-x86_64-8.3.3.40_cuda11.5-archive.tar.xz";
         hash = "sha256-6r6Wx1zwPqT1N5iU2RTx+K4UzqsSGYnoSwg22Sf7dzE=";
       }
-      {
-        version = "8.4.1.50";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.4.1.50_cuda10.2-archive.tar.xz";
-        hash = "sha256-I88qMmU6lIiLVmaPuX7TTbisgTav839mssxUo3lQNjg=";
-      }
       {
         version = "8.4.1.50";
         minCudaVersion = "11.0";
@@ -208,13 +138,6 @@
         url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.4.1.50_cuda11.6-archive.tar.xz";
         hash = "sha256-7JbSN22B/KQr3T1MPXBambKaBlurV/kgVhx2PinGfQE=";
       }
-      {
-        version = "8.5.0.96";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.5.0.96_cuda10-archive.tar.xz";
-        hash = "sha256-1mzhbbzR40WKkHnQLtJHhg0vYgf7G8a0OBcCwIOkJjM=";
-      }
       {
         version = "8.5.0.96";
         minCudaVersion = "11.0";
@@ -222,13 +145,6 @@
         url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.5.0.96_cuda11-archive.tar.xz";
         hash = "sha256-VFSm/ZTwCHKMqumtrZk8ToXvNjAuJrzkO+p9RYpee20=";
       }
-      {
-        version = "8.6.0.163";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.6.0.163_cuda10-archive.tar.xz";
-        hash = "sha256-t4sr/GrFqqdxu2VhaJQk5K1Xm/0lU4chXG8hVL09R9k=";
-      }
       {
         version = "8.6.0.163";
         minCudaVersion = "11.0";
@@ -236,13 +152,6 @@
         url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.6.0.163_cuda11-archive.tar.xz";
         hash = "sha256-u8OW30cpTGV+3AnGAGdNYIyxv8gLgtz0VHBgwhcRFZ4=";
       }
-      {
-        version = "8.7.0.84";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        url = "https://developer.download.nvidia.com/compute/cudnn/redist/cudnn/linux-x86_64/cudnn-linux-x86_64-8.7.0.84_cuda10-archive.tar.xz";
-        hash = "sha256-bZhaqc8+GbPV2FQvvbbufd8VnEJgvfkICc2N3/gitRg=";
-      }
       {
         version = "8.7.0.84";
         minCudaVersion = "11.0";
diff --git a/pkgs/development/cuda-modules/cutensor/extension.nix b/pkgs/development/cuda-modules/cutensor/extension.nix
index 1f6ea3655242..2abffe025d63 100644
--- a/pkgs/development/cuda-modules/cutensor/extension.nix
+++ b/pkgs/development/cuda-modules/cutensor/extension.nix
@@ -101,10 +101,7 @@ let
     (attrsets.attrByPath [
       pname
       redistArch
-    ] null feature) != null
-
-    # NOTE: This is an ad hoc hack; manifest schemas do not support version constraints yet
-    && !(lib.versionOlder cudaVersion "11.0" && lib.versionAtLeast redistrib.${pname}.version "2.0.2");
+    ] null feature) != null;
 
   # TODO(@connorbaker): With an auxilliary file keeping track of the CUDA versions each release supports,
   # we could filter out releases that don't support our CUDA version.
diff --git a/pkgs/development/cuda-modules/gpus.nix b/pkgs/development/cuda-modules/gpus.nix
index cf6e0a1eaf36..15f98be92cd0 100644
--- a/pkgs/development/cuda-modules/gpus.nix
+++ b/pkgs/development/cuda-modules/gpus.nix
@@ -27,23 +27,6 @@
 # Without your work, this would have been much more difficult.
 # https://arnon.dk/matching-sm-architectures-arch-and-gencode-for-various-nvidia-cards/
 [
-  {
-    # GeForce 700, GT-730
-    archName = "Kepler";
-    computeCapability = "3.0";
-    isJetson = false;
-    minCudaVersion = "10.0";
-    dontDefaultAfter = "10.2";
-    maxCudaVersion = "10.2";
-  }
-  {
-    archName = "Kepler";
-    computeCapability = "3.2";
-    isJetson = false;
-    minCudaVersion = "10.0";
-    dontDefaultAfter = "10.2";
-    maxCudaVersion = "10.2";
-  }
   {
     # Tesla K40
     archName = "Kepler";
diff --git a/pkgs/development/cuda-modules/nvcc-compatibilities.nix b/pkgs/development/cuda-modules/nvcc-compatibilities.nix
index d4189400e2fc..eb73cd93edfe 100644
--- a/pkgs/development/cuda-modules/nvcc-compatibilities.nix
+++ b/pkgs/development/cuda-modules/nvcc-compatibilities.nix
@@ -22,28 +22,6 @@ let
   # attrs :: AttrSet CudaVersion CompilerCompatibilities
   attrs = {
     # Our baseline
-    # https://docs.nvidia.com/cuda/archive/10.0/cuda-toolkit-release-notes/index.html#cuda-compiler-new-features
-    "10.0" = {
-      clangMaxMajorVersion = "6";
-      clangMinMajorVersion = "6";
-      gccMaxMajorVersion = "7";
-      gccMinMajorVersion = "5";
-    };
-
-    # Added support for Clang 7 and GCC 8
-    # https://docs.nvidia.com/cuda/archive/10.1/cuda-toolkit-release-notes/index.html#cuda-compiler-new-features
-    "10.1" = attrs."10.0" // {
-      clangMaxMajorVersion = "7";
-      gccMaxMajorVersion = "8";
-    };
-
-    # Added clang 8
-    # https://docs.nvidia.com/cuda/archive/10.2/cuda-toolkit-release-notes/index.html#cuda-compiler-new-features
-    "10.2" = attrs."10.1" // {
-      clangMaxMajorVersion = "8";
-    };
-
-    # Added support for Clang 9 and GCC 9
     # https://docs.nvidia.com/cuda/archive/11.0/cuda-toolkit-release-notes/index.html#cuda-compiler-new-features
     "11.0" = {
       clangMaxMajorVersion = "9";
diff --git a/pkgs/development/cuda-modules/tensorrt/releases.nix b/pkgs/development/cuda-modules/tensorrt/releases.nix
index e8c75b6ccdee..c42218eebe96 100644
--- a/pkgs/development/cuda-modules/tensorrt/releases.nix
+++ b/pkgs/development/cuda-modules/tensorrt/releases.nix
@@ -43,14 +43,6 @@
     ];
     # x86_64
     linux-x86_64 = [
-      {
-        version = "8.0.3.4";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        cudnnVersion = "8.2";
-        filename = "TensorRT-8.0.3.4.Linux.x86_64-gnu.cuda-10.2.cudnn8.2.tar.gz";
-        hash = "sha256-LxcXgwe1OCRfwDsEsNLIkeNsOcx3KuF5Sj+g2dY6WD0=";
-      }
       {
         version = "8.0.3.4";
         minCudaVersion = "11.0";
@@ -59,14 +51,6 @@
         filename = "TensorRT-8.0.3.4.Linux.x86_64-gnu.cuda-11.3.cudnn8.2.tar.gz";
         hash = "sha256-MXdDUCT/SqWm26jB7QarEcwOG/O7cS36Y6Q0IvQTE/M=";
       }
-      {
-        version = "8.2.5.1";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        cudnnVersion = "8.2";
-        filename = "TensorRT-8.2.5.1.Linux.x86_64-gnu.cuda-10.2.cudnn8.2.tar.gz";
-        hash = "sha256-XV2Bf2LH8OM2GEMjV80MDweb1hSVF/wFUcaW3KP2m8Q=";
-      }
       {
         # The docs claim this supports through 11.5 despite the file name indicating 11.4.
         version = "8.2.5.1";
@@ -76,14 +60,6 @@
         filename = "TensorRT-8.2.5.1.Linux.x86_64-gnu.cuda-11.4.cudnn8.2.tar.gz";
         hash = "sha256-LcNpYvDiT7AavqzK1MRlijo2qDN7jznigeS77US713E=";
       }
-      {
-        version = "8.4.3.1";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        cudnnVersion = "8.4";
-        filename = "TensorRT-8.4.3.1.Linux.x86_64-gnu.cuda-10.2.cudnn8.4.tar.gz";
-        hash = "sha256-2c3Zzt93FBWWQtrSIvpbzzS6BT9s0NzALzdwXGLOZEU=";
-      }
       {
         # The docs claim this supports through 11.7 despite the file name indicating 11.6.
         version = "8.4.3.1";
@@ -93,14 +69,6 @@
         filename = "TensorRT-8.4.3.1.Linux.x86_64-gnu.cuda-11.6.cudnn8.4.tar.gz";
         hash = "sha256-jXwghcFjncxzh1BIwjWYqFJs4wiRNoduMdkCWOSeT2E=";
       }
-      {
-        version = "8.5.3.1";
-        minCudaVersion = "10.2";
-        maxCudaVersion = "10.2";
-        cudnnVersion = "8.6";
-        filename = "TensorRT-8.5.3.1.Linux.x86_64-gnu.cuda-10.2.cudnn8.6.tar.gz";
-        hash = "sha256-WCt6yfOmFbrjqdYCj6AE2+s2uFpISwk6urP+2I0BnGQ=";
-      }
       {
         version = "8.5.3.1";
         minCudaVersion = "11.0";
diff --git a/pkgs/test/cuda/default.nix b/pkgs/test/cuda/default.nix
index b6d9ec4294c0..02b72cdb83de 100644
--- a/pkgs/test/cuda/default.nix
+++ b/pkgs/test/cuda/default.nix
@@ -4,11 +4,6 @@
 
   cudaPackages,
 
-  cudaPackages_10_0,
-  cudaPackages_10_1,
-  cudaPackages_10_2,
-  cudaPackages_10,
-
   cudaPackages_11_0,
   cudaPackages_11_1,
   cudaPackages_11_2,
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 5173b3dc0dda..bfa9d66f486f 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -182,6 +182,7 @@ mapAliases {
 
   ### C ###
 
+  caffeWithCuda = throw "caffeWithCuda has been removed, as it was broken and required CUDA 10"; # Added 2024-11-20
   calligra = kdePackages.calligra; # Added 2024-09-27
   callPackage_i686 = pkgsi686Linux.callPackage;
   cask = emacs.pkgs.cask; # Added 2022-11-12
@@ -236,6 +237,10 @@ mapAliases {
   containerpilot = throw "'containerpilot' has been removed from nixpkgs, as it was broken and unmaintained"; # Added 2024-06-09
   crackmapexec = throw "'crackmapexec' has been removed as it was unmaintained. Use 'netexec' instead"; # 2024-08-11
   critcl = tclPackages.critcl; # Added 2024-10-02
+  cudaPackages_10_0 = throw "CUDA 10.0 has been removed from Nixpkgs, as it is unmaintained upstream and depends on unsupported compilers"; # Added 2024-11-20
+  cudaPackages_10_1 = throw "CUDA 10.1 has been removed from Nixpkgs, as it is unmaintained upstream and depends on unsupported compilers"; # Added 2024-11-20
+  cudaPackages_10_2 = throw "CUDA 10.2 has been removed from Nixpkgs, as it is unmaintained upstream and depends on unsupported compilers"; # Added 2024-11-20
+  cudaPackages_10 = throw "CUDA 10 has been removed from Nixpkgs, as it is unmaintained upstream and depends on unsupported compilers"; # Added 2024-11-20
   cups-kyodialog3 = cups-kyodialog; # Added 2022-11-12
   cvs_fast_export = throw "'cvs_fast_export' has been renamed to/replaced by 'cvs-fast-export'"; # Converted to throw 2024-10-17
 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index ece00bdbe358..b2063c9ecfdd 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -3088,11 +3088,6 @@ with pkgs;
 
   cron = isc-cron;
 
-  cudaPackages_10_0 = callPackage ./cuda-packages.nix { cudaVersion = "10.0"; };
-  cudaPackages_10_1 = callPackage ./cuda-packages.nix { cudaVersion = "10.1"; };
-  cudaPackages_10_2 = callPackage ./cuda-packages.nix { cudaVersion = "10.2"; };
-  cudaPackages_10 = recurseIntoAttrs cudaPackages_10_2;
-
   cudaPackages_11_0 = callPackage ./cuda-packages.nix { cudaVersion = "11.0"; };
   cudaPackages_11_1 = callPackage ./cuda-packages.nix { cudaVersion = "11.1"; };
   cudaPackages_11_2 = callPackage ./cuda-packages.nix { cudaVersion = "11.2"; };
@@ -18060,15 +18055,11 @@ with pkgs;
   ### SCIENCE / MATH
 
   caffe = callPackage ../applications/science/math/caffe ({
-    inherit (config) cudaSupport;
-    cudaPackages = cudaPackages_10_1;
     opencv4 = opencv4WithoutCuda; # Used only for image loading.
     blas = openblas;
     inherit (darwin.apple_sdk.frameworks) Accelerate CoreGraphics CoreVideo;
   } // (config.caffe or {}));
 
-  caffeWithCuda = caffe.override { cudaSupport = true; };
-
   gap-minimal = lowPrio (gap.override { packageSet = "minimal"; });
 
   gap-full = lowPrio (gap.override { packageSet = "full"; });
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 27a73c44ae36..98f605fa667b 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -101,6 +101,7 @@ mapAliases ({
   BTrees = btrees; # added 2023-02-19
   cacheyou = throw "cacheyou has been removed, as it was no longer used for the only consumer pdm"; # added 2023-12-21
   cadquery = throw "cadquery was removed, because it was disabled on all python version since 3.8 and marked as broken"; # added 2024-05-13
+  caffeWithCuda = throw "caffeWithCuda has been removed, as it was broken and required CUDA 10"; # Added 2024-11-20
   can = python-can; # added 2024-08-12
   carrot = throw "carrot has been removed, as its development was discontinued in 2012"; # added 2022-01-18
   case = throw "case has been removed, since it is an unused leaf package with a dependency on the nose test framework"; # added 2024-07-08
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index c36115340905..b9010ea5411d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1989,11 +1989,6 @@ self: super: with self; {
     inherit (self) python numpy boost;
   });
 
-  caffeWithCuda = toPythonModule (pkgs.caffeWithCuda.override {
-    pythonSupport = true;
-    inherit (self) python numpy boost;
-  });
-
   caio = callPackage ../development/python-modules/caio { };
 
   cairocffi = callPackage ../development/python-modules/cairocffi { };
diff --git a/pkgs/top-level/release-cuda.nix b/pkgs/top-level/release-cuda.nix
index f655114737e9..945f0e6d2954 100644
--- a/pkgs/top-level/release-cuda.nix
+++ b/pkgs/top-level/release-cuda.nix
@@ -118,7 +118,6 @@ let
       python3Packages = {
         boxx = linux;
         bpycv = linux;
-        caffe = linux;
         catboost = linux;
         chainer = linux;
         cupy = linux;