diff --git a/pkgs/development/web/nodejs/nodejs.nix b/pkgs/development/web/nodejs/nodejs.nix
index e08e84ee7f22..014795f7425a 100644
--- a/pkgs/development/web/nodejs/nodejs.nix
+++ b/pkgs/development/web/nodejs/nodejs.nix
@@ -302,22 +302,10 @@ let
         "test-process-setgroups"
         "test-process-uid-gid"
         "test-setproctitle"
-        "test-tls-cert-regression"
         "test-tls-cli-max-version-1.3"
         "test-tls-client-auth"
-        "test-tls-client-getephemeralkeyinfo"
-        "test-tls-client-mindhsize"
-        "test-tls-client-renegotiation-13"
-        "test-tls-client-verify"
-        "test-tls-getcipher"
         "test-tls-junk-closes-server"
-        "test-tls-junk-server"
-        "test-tls-multi-key"
-        "test-tls-multiple-cas-as-string"
-        "test-tls-peer-certificate-encoding"
-        "test-tls-set-ciphers"
         "test-tls-sni-option"
-        "test-tls-sni-server-client"
         # This is a bit weird, but for some reason fs watch tests fail with
         # sandbox.
         "test-fs-promises-watch"
diff --git a/pkgs/development/web/nodejs/v18.nix b/pkgs/development/web/nodejs/v18.nix
index 811c0646959e..d940613ecb78 100644
--- a/pkgs/development/web/nodejs/v18.nix
+++ b/pkgs/development/web/nodejs/v18.nix
@@ -48,5 +48,64 @@ buildNodejs {
       url = "https://github.com/nodejs/node/commit/d0a6b605fba6cd69a82e6f12ff0363eef8fe1ee9.patch";
       hash = "sha256-TfYal/PikRZHL6zpAlC3SmkYXCe+/8Gs83dLX/X/P/k=";
     })
+
+    # Patches for OpenSSL 3.2
+    # Patches already in 22.7.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/bd42e4c6a73f61f7ee47e4426d86708fd80c6c4f.patch?full_index=1";
+      hash = "sha256-bsCLVwK5t8dD+wHd1FlFJ1wpCGtNGcwoOfq4fG5MHfo=";
+      includes = ["test/parallel/test-tls-set-sigalgs.js"];
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/e0634f58aba6a1634fe03107d5be849fd008cc02.patch?full_index=1";
+      hash = "sha256-Jh7f4JPS1H2Rpj1nEOW53E66Z+GDNEFXl0jALrvyYXQ=";
+    })
+    # Patches already in 22.8.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/e9cd4766e39d96693320be9ce0a1044c450e8675.patch?full_index=1";
+      hash = "sha256-RXRLRznz16B8MrfVrpIHgyqLV2edpJk2p717QBttyK4=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/2bfc9e467cb05578efa4d3db497f368fb144e5fc.patch?full_index=1";
+      hash = "sha256-TyHSd+O0T/bFR7YZuxm4HumrMljnJu2a8RRLRvz6KNM=";
+    })
+    # Patches already in 22.9.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/d9ca8b018efd172a99365ada8f536491b19bd87b.patch?full_index=1";
+      hash = "sha256-KzoWVXcgjJaMUOXDyLlkwRcN6z3SdFhTJd0KYBYfElE=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/c4f295470392db237c0adfc9832214538a99a034.patch?full_index=1";
+      hash = "sha256-sYTY+oiQ5K7bYLcI1+jSTlLFdwpteKGSu7S/bbaslLE=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/a65105ec284023960e93b3a66f6661ddd2f4121f.patch?full_index=1";
+      hash = "sha256-ZNkiHlp+UlbnonPBhMUw6rqtjWrC1b9SgI9EcGhDlwY=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/c77bcf018716e97ae35203990bcd51c143840348.patch?full_index=1";
+      hash = "sha256-EwrZKpLRzk3Yjen1WVQqKTiHKE2uLTpaPsE13czH2rY=";
+    })
+    # Patches not yet released
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/f8b7a171463e775da304bccf4cf165e634525c7e.patch?full_index=1";
+      hash = "sha256-imptUwt2oG8pPGKD3V6m5NQXuahis71UpXiJm4C0E6o=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/6dfa3e46d3d2f8cfba7da636d48a5c41b0132cd7.patch?full_index=1";
+      hash = "sha256-ITtGsvZI6fliirCKvbMH9N2Xoy3001bz+hS3NPoqvzg=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/29b9c72b05786061cde58a5ae11cfcb580ab6c28.patch?full_index=1";
+      hash = "sha256-xaqtwsrOIyRV5zzccab+nDNG8kUgO6AjrVYJNmjeNP0=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/cfe58cfdc488da71e655d3da709292ce6d9ddb58.patch?full_index=1";
+      hash = "sha256-9GblpbQcYfoiE5R7fETsdW7v1Mm2Xdr4+xRNgUpLO+8=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/2cec716c48cea816dcd5bf4997ae3cdf1fe4cd90.patch?full_index=1";
+      hash = "sha256-ExIkAj8yRJEK39OfV6A53HiuZsfQOm82/Tvj0nCaI8A=";
+    })
   ] ++ gypPatches;
 }
diff --git a/pkgs/development/web/nodejs/v20.nix b/pkgs/development/web/nodejs/v20.nix
index bb2a446d6eef..cf3cb89167b5 100644
--- a/pkgs/development/web/nodejs/v20.nix
+++ b/pkgs/development/web/nodejs/v20.nix
@@ -1,4 +1,4 @@
-{ callPackage, openssl, python3, enableNpm ? true }:
+{ callPackage, fetchpatch2, openssl, python3, enableNpm ? true }:
 
 let
   buildNodejs = callPackage ./nodejs.nix {
@@ -21,5 +21,64 @@ buildNodejs {
     ./bypass-darwin-xcrun-node16.patch
     ./node-npm-build-npm-package-logic.patch
     ./use-correct-env-in-tests.patch
+
+    # Patches for OpenSSL 3.2
+    # Patches already in 22.7.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/bd42e4c6a73f61f7ee47e4426d86708fd80c6c4f.patch?full_index=1";
+      hash = "sha256-bsCLVwK5t8dD+wHd1FlFJ1wpCGtNGcwoOfq4fG5MHfo=";
+      includes = ["test/parallel/test-tls-set-sigalgs.js"];
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/e0634f58aba6a1634fe03107d5be849fd008cc02.patch?full_index=1";
+      hash = "sha256-Jh7f4JPS1H2Rpj1nEOW53E66Z+GDNEFXl0jALrvyYXQ=";
+    })
+    # Patches already in 22.8.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/e9cd4766e39d96693320be9ce0a1044c450e8675.patch?full_index=1";
+      hash = "sha256-RXRLRznz16B8MrfVrpIHgyqLV2edpJk2p717QBttyK4=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/2bfc9e467cb05578efa4d3db497f368fb144e5fc.patch?full_index=1";
+      hash = "sha256-TyHSd+O0T/bFR7YZuxm4HumrMljnJu2a8RRLRvz6KNM=";
+    })
+    # Patches already in 22.9.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/d9ca8b018efd172a99365ada8f536491b19bd87b.patch?full_index=1";
+      hash = "sha256-KzoWVXcgjJaMUOXDyLlkwRcN6z3SdFhTJd0KYBYfElE=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/c4f295470392db237c0adfc9832214538a99a034.patch?full_index=1";
+      hash = "sha256-sYTY+oiQ5K7bYLcI1+jSTlLFdwpteKGSu7S/bbaslLE=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/a65105ec284023960e93b3a66f6661ddd2f4121f.patch?full_index=1";
+      hash = "sha256-ZNkiHlp+UlbnonPBhMUw6rqtjWrC1b9SgI9EcGhDlwY=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/c77bcf018716e97ae35203990bcd51c143840348.patch?full_index=1";
+      hash = "sha256-EwrZKpLRzk3Yjen1WVQqKTiHKE2uLTpaPsE13czH2rY=";
+    })
+    # Patches not yet released
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/f8b7a171463e775da304bccf4cf165e634525c7e.patch?full_index=1";
+      hash = "sha256-imptUwt2oG8pPGKD3V6m5NQXuahis71UpXiJm4C0E6o=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/6dfa3e46d3d2f8cfba7da636d48a5c41b0132cd7.patch?full_index=1";
+      hash = "sha256-ITtGsvZI6fliirCKvbMH9N2Xoy3001bz+hS3NPoqvzg=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/29b9c72b05786061cde58a5ae11cfcb580ab6c28.patch?full_index=1";
+      hash = "sha256-xaqtwsrOIyRV5zzccab+nDNG8kUgO6AjrVYJNmjeNP0=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/cfe58cfdc488da71e655d3da709292ce6d9ddb58.patch?full_index=1";
+      hash = "sha256-9GblpbQcYfoiE5R7fETsdW7v1Mm2Xdr4+xRNgUpLO+8=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/2cec716c48cea816dcd5bf4997ae3cdf1fe4cd90.patch?full_index=1";
+      hash = "sha256-ExIkAj8yRJEK39OfV6A53HiuZsfQOm82/Tvj0nCaI8A=";
+    })
   ] ++ gypPatches;
 }
diff --git a/pkgs/development/web/nodejs/v22.nix b/pkgs/development/web/nodejs/v22.nix
index 90174977ffa9..4d539aac90b9 100644
--- a/pkgs/development/web/nodejs/v22.nix
+++ b/pkgs/development/web/nodejs/v22.nix
@@ -1,4 +1,4 @@
-{ callPackage, openssl, python3, enableNpm ? true }:
+{ callPackage, fetchpatch2, openssl, python3, enableNpm ? true }:
 
 let
   buildNodejs = callPackage ./nodejs.nix {
@@ -7,7 +7,6 @@ let
   };
 
   gypPatches = callPackage ./gyp-patches.nix { } ++ [
-    ./gyp-patches-v22-import-sys.patch
   ];
 in
 buildNodejs {
@@ -22,5 +21,45 @@ buildNodejs {
     ./node-npm-build-npm-package-logic.patch
     ./use-correct-env-in-tests.patch
     ./bin-sh-node-run-v22.patch
+
+    # Patches for OpenSSL 3.2
+    # Patches already in 22.9.0
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/d9ca8b018efd172a99365ada8f536491b19bd87b.patch?full_index=1";
+      hash = "sha256-KzoWVXcgjJaMUOXDyLlkwRcN6z3SdFhTJd0KYBYfElE=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/c4f295470392db237c0adfc9832214538a99a034.patch?full_index=1";
+      hash = "sha256-sYTY+oiQ5K7bYLcI1+jSTlLFdwpteKGSu7S/bbaslLE=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/a65105ec284023960e93b3a66f6661ddd2f4121f.patch?full_index=1";
+      hash = "sha256-ZNkiHlp+UlbnonPBhMUw6rqtjWrC1b9SgI9EcGhDlwY=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/c77bcf018716e97ae35203990bcd51c143840348.patch?full_index=1";
+      hash = "sha256-EwrZKpLRzk3Yjen1WVQqKTiHKE2uLTpaPsE13czH2rY=";
+    })
+    # Patches not yet released
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/f8b7a171463e775da304bccf4cf165e634525c7e.patch?full_index=1";
+      hash = "sha256-imptUwt2oG8pPGKD3V6m5NQXuahis71UpXiJm4C0E6o=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/6dfa3e46d3d2f8cfba7da636d48a5c41b0132cd7.patch?full_index=1";
+      hash = "sha256-ITtGsvZI6fliirCKvbMH9N2Xoy3001bz+hS3NPoqvzg=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/29b9c72b05786061cde58a5ae11cfcb580ab6c28.patch?full_index=1";
+      hash = "sha256-xaqtwsrOIyRV5zzccab+nDNG8kUgO6AjrVYJNmjeNP0=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/cfe58cfdc488da71e655d3da709292ce6d9ddb58.patch?full_index=1";
+      hash = "sha256-9GblpbQcYfoiE5R7fETsdW7v1Mm2Xdr4+xRNgUpLO+8=";
+    })
+    (fetchpatch2 {
+      url = "https://github.com/nodejs/node/commit/2cec716c48cea816dcd5bf4997ae3cdf1fe4cd90.patch?full_index=1";
+      hash = "sha256-ExIkAj8yRJEK39OfV6A53HiuZsfQOm82/Tvj0nCaI8A=";
+    })
   ] ++ gypPatches;
 }