diff --git a/src/cmd/cgo/main.go b/src/cmd/cgo/main.go
index ef7275023a..cbc9d16da5 100644
--- a/src/cmd/cgo/main.go
+++ b/src/cmd/cgo/main.go
@@ -11,10 +11,12 @@
 package main
 
 import (
+	"crypto/md5"
 	"flag"
 	"fmt"
 	"go/ast"
 	"go/token"
+	"io"
 	"os"
 	"reflect"
 	"strings"
@@ -105,6 +107,8 @@ var ptrSizeMap = map[string]int64{
 	"arm":   4,
 }
 
+var cPrefix string
+
 var fset = token.NewFileSet()
 
 var dynobj = flag.String("dynimport", "", "if non-empty, print dynamic import data for that file")
@@ -170,6 +174,22 @@ func main() {
 		Written:    make(map[string]bool),
 	}
 
+	// Need a unique prefix for the global C symbols that
+	// we use to coordinate between gcc and ourselves.
+	// We already put _cgo_ at the beginning, so the main
+	// concern is other cgo wrappers for the same functions.
+	// Use the beginning of the md5 of the input to disambiguate.
+	h := md5.New()
+	for _, input := range goFiles {
+		f, err := os.Open(input, os.O_RDONLY, 0)
+		if err != nil {
+			fatal("%s", err)
+		}
+		io.Copy(h, f)
+		f.Close()
+	}
+	cPrefix = fmt.Sprintf("_%x", h.Sum()[0:6])
+
 	for _, input := range goFiles {
 		f := new(File)
 		// Reset f.Preamble so that we don't end up with conflicting headers / defines
diff --git a/src/cmd/cgo/out.go b/src/cmd/cgo/out.go
index c7db2c7cc0..d6b25d5c19 100644
--- a/src/cmd/cgo/out.go
+++ b/src/cmd/cgo/out.go
@@ -212,12 +212,12 @@ func (p *Package) writeDefsFunc(fc, fgo2 *os.File, n *Name, soprefix, sopath str
 	_, argSize = p.structType(n)
 
 	// C wrapper calls into gcc, passing a pointer to the argument frame.
-	fmt.Fprintf(fc, "void _cgo%s(void*);\n", n.Mangle)
+	fmt.Fprintf(fc, "void _cgo%s%s(void*);\n", cPrefix, n.Mangle)
 	fmt.Fprintf(fc, "\n")
 	fmt.Fprintf(fc, "void\n")
 	fmt.Fprintf(fc, "·%s(struct{uint8 x[%d];}p)\n", n.Mangle, argSize)
 	fmt.Fprintf(fc, "{\n")
-	fmt.Fprintf(fc, "\truntime·cgocall(_cgo%s, &p);\n", n.Mangle)
+	fmt.Fprintf(fc, "\truntime·cgocall(_cgo%s%s, &p);\n", cPrefix, n.Mangle)
 	if n.AddError {
 		// gcc leaves errno in first word of interface at end of p.
 		// check whether it is zero; if so, turn interface into nil.
@@ -292,7 +292,7 @@ func (p *Package) writeOutputFunc(fgcc *os.File, n *Name) {
 	// Gcc wrapper unpacks the C argument struct
 	// and calls the actual C function.
 	fmt.Fprintf(fgcc, "void\n")
-	fmt.Fprintf(fgcc, "_cgo%s(void *v)\n", n.Mangle)
+	fmt.Fprintf(fgcc, "_cgo%s%s(void *v)\n", cPrefix, n.Mangle)
 	fmt.Fprintf(fgcc, "{\n")
 	if n.AddError {
 		fmt.Fprintf(fgcc, "\tint e;\n") // assuming 32 bit (see comment above structType)