diff --git a/src/runtime/crash_cgo_test.go b/src/runtime/crash_cgo_test.go
index 972eedc624e..98c4c1c0d45 100644
--- a/src/runtime/crash_cgo_test.go
+++ b/src/runtime/crash_cgo_test.go
@@ -50,6 +50,18 @@ func TestCgoExternalThreadPanic(t *testing.T) {
 	}
 }
 
+func TestCgoExternalThreadSIGPROF(t *testing.T) {
+	// issue 9456.
+	if runtime.GOOS == "plan9" || runtime.GOOS == "windows" {
+		t.Skipf("no pthreads on %s", runtime.GOOS)
+	}
+	got := executeTest(t, cgoExternalThreadSIGPROFSource, nil)
+	want := "OK\n"
+	if got != want {
+		t.Fatalf("expected %q, but got %q", want, got)
+	}
+}
+
 const cgoSignalDeadlockSource = `
 package main
 
@@ -194,3 +206,46 @@ start(void)
 		printf("_beginthreadex failed\n");
 }
 `
+
+const cgoExternalThreadSIGPROFSource = `
+package main
+
+/*
+#include <stdint.h>
+#include <signal.h>
+#include <pthread.h>
+
+volatile int32_t spinlock;
+
+static void *thread1(void *p) {
+	(void)p;
+	while (spinlock == 0)
+		;
+	pthread_kill(pthread_self(), SIGPROF);
+	spinlock = 0;
+	return NULL;
+}
+__attribute__((constructor)) void issue9456() {
+	pthread_t tid;
+	pthread_create(&tid, 0, thread1, NULL);
+}
+*/
+import "C"
+
+import (
+	"runtime"
+	"sync/atomic"
+	"unsafe"
+)
+
+func main() {
+	// This test intends to test that sending SIGPROF to foreign threads
+	// before we make any cgo call will not abort the whole process, so
+	// we cannot make any cgo call here. See http://golang.org/issue/9456.
+	atomic.StoreInt32((*int32)(unsafe.Pointer(&C.spinlock)), 1)
+	for atomic.LoadInt32((*int32)(unsafe.Pointer(&C.spinlock))) == 1 {
+		runtime.Gosched()
+	}
+	println("OK")
+}
+`
diff --git a/src/runtime/sigqueue.go b/src/runtime/sigqueue.go
index 4b97745a23f..a7607903969 100644
--- a/src/runtime/sigqueue.go
+++ b/src/runtime/sigqueue.go
@@ -154,5 +154,14 @@ func signal_disable(s uint32) {
 // This runs on a foreign stack, without an m or a g.  No stack split.
 //go:nosplit
 func badsignal(sig uintptr) {
+	// Some external libraries, for example, OpenBLAS, create worker threads in
+	// a global constructor. If we're doing cpu profiling, and the SIGPROF signal
+	// comes to one of the foreign threads before we make our first cgo call, the
+	// call to cgocallback below will bring down the whole process.
+	// It's better to miss a few SIGPROF signals than to abort in this case.
+	// See http://golang.org/issue/9456.
+	if sig == _SIGPROF && needextram != 0 {
+		return
+	}
 	cgocallback(unsafe.Pointer(funcPC(sigsend)), noescape(unsafe.Pointer(&sig)), unsafe.Sizeof(sig))
 }