diff --git a/src/cmd/go/internal/work/init.go b/src/cmd/go/internal/work/init.go
index c8fee098e05..48c91d54b32 100644
--- a/src/cmd/go/internal/work/init.go
+++ b/src/cmd/go/internal/work/init.go
@@ -162,7 +162,9 @@ func instrumentInit() {
 	}
 	modeFlag := "-" + mode
 
-	if !cfg.BuildContext.CgoEnabled {
+	// Check that cgo is enabled.
+	// Note: On macOS, -race does not require cgo. -asan and -msan still do.
+	if !cfg.BuildContext.CgoEnabled && (cfg.Goos != "darwin" || cfg.BuildASan || cfg.BuildMSan) {
 		if runtime.GOOS != cfg.Goos || runtime.GOARCH != cfg.Goarch {
 			fmt.Fprintf(os.Stderr, "go: %s requires cgo\n", modeFlag)
 		} else {
diff --git a/src/cmd/go/testdata/script/install_msan_and_race_and_asan_require_cgo.txt b/src/cmd/go/testdata/script/install_msan_and_race_and_asan_require_cgo.txt
index 0c68e2cf1bd..d8f2abaf3f1 100644
--- a/src/cmd/go/testdata/script/install_msan_and_race_and_asan_require_cgo.txt
+++ b/src/cmd/go/testdata/script/install_msan_and_race_and_asan_require_cgo.txt
@@ -2,9 +2,11 @@
 
 env CGO_ENABLED=0
 
-[race] ! go install -race triv.go
-[race] stderr '-race requires cgo'
-[race] ! stderr '-msan'
+[GOOS:darwin] [!short] [race] go build -race triv.go
+
+[!GOOS:darwin] [race] ! go install -race triv.go
+[!GOOS:darwin] [race] stderr '-race requires cgo'
+[!GOOS:darwin] [race] ! stderr '-msan'
 
 [msan] ! go install -msan triv.go
 [msan] stderr '-msan requires cgo'
diff --git a/src/runtime/race.go b/src/runtime/race.go
index f68e1aeaaca..40b6e003981 100644
--- a/src/runtime/race.go
+++ b/src/runtime/race.go
@@ -360,8 +360,8 @@ func isvalidaddr(addr unsafe.Pointer) bool {
 
 //go:nosplit
 func raceinit() (gctx, pctx uintptr) {
-	// cgo is required to initialize libc, which is used by race runtime
-	if !iscgo {
+	// On most machines, cgo is required to initialize libc, which is used by race runtime.
+	if !iscgo && GOOS != "darwin" {
 		throw("raceinit: race build must use cgo")
 	}
 
diff --git a/src/runtime/race/doc.go b/src/runtime/race/doc.go
index 9e93f660421..60a20df5bfb 100644
--- a/src/runtime/race/doc.go
+++ b/src/runtime/race/doc.go
@@ -7,3 +7,5 @@
 // For details about the race detector see
 // https://golang.org/doc/articles/race_detector.html
 package race
+
+//go:generate ./mkcgo.sh
diff --git a/src/runtime/race/mkcgo.sh b/src/runtime/race/mkcgo.sh
new file mode 100755
index 00000000000..6ebe5a4fc7d
--- /dev/null
+++ b/src/runtime/race/mkcgo.sh
@@ -0,0 +1,20 @@
+#!/bin/bash
+
+hdr='
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// Code generated by mkcgo.sh. DO NOT EDIT.
+
+//go:build race
+
+'
+
+convert() {
+	(echo "$hdr"; go tool cgo -dynpackage race -dynimport $1) | gofmt
+}
+
+convert race_darwin_arm64.syso >race_darwin_arm64.go
+convert internal/amd64v1/race_darwin.syso >race_darwin_amd64.go
+
diff --git a/src/runtime/race/race.go b/src/runtime/race/race.go
index 8692066341c..9c508ebc2b3 100644
--- a/src/runtime/race/race.go
+++ b/src/runtime/race/race.go
@@ -2,7 +2,7 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (race && linux && amd64) || (race && freebsd && amd64) || (race && netbsd && amd64) || (race && darwin && amd64) || (race && windows && amd64) || (race && linux && ppc64le) || (race && linux && arm64) || (race && darwin && arm64) || (race && openbsd && amd64) || (race && linux && s390x)
+//go:build race && ((linux && (amd64 || arm64 || ppc64le || s390x)) || ((freebsd || netbsd || openbsd || windows) && amd64))
 
 package race
 
@@ -11,5 +11,10 @@ package race
 // The prebuilt race runtime lives in race_GOOS_GOARCH.syso.
 // Calls to the runtime are done directly from src/runtime/race.go.
 
+// On darwin we always use system DLLs to create threads,
+// so we use race_darwin_$GOARCH.go to provide the syso-derived
+// symbol information without needing to invoke cgo.
+// This allows -race to be used on Mac systems without a C toolchain.
+
 // void __race_unused_func(void);
 import "C"
diff --git a/src/runtime/race/race_darwin_amd64.go b/src/runtime/race/race_darwin_amd64.go
new file mode 100644
index 00000000000..fbb838aa2e4
--- /dev/null
+++ b/src/runtime/race/race_darwin_amd64.go
@@ -0,0 +1,101 @@
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// Code generated by mkcgo.sh. DO NOT EDIT.
+
+//go:build race
+
+package race
+
+//go:cgo_import_dynamic _Block_object_assign _Block_object_assign ""
+//go:cgo_import_dynamic _Block_object_dispose _Block_object_dispose ""
+//go:cgo_import_dynamic _NSConcreteStackBlock _NSConcreteStackBlock ""
+//go:cgo_import_dynamic _NSGetArgv _NSGetArgv ""
+//go:cgo_import_dynamic _NSGetEnviron _NSGetEnviron ""
+//go:cgo_import_dynamic _NSGetExecutablePath _NSGetExecutablePath ""
+//go:cgo_import_dynamic __bzero __bzero ""
+//go:cgo_import_dynamic __error __error ""
+//go:cgo_import_dynamic __fork __fork ""
+//go:cgo_import_dynamic __mmap __mmap ""
+//go:cgo_import_dynamic __munmap __munmap ""
+//go:cgo_import_dynamic __stack_chk_fail __stack_chk_fail ""
+//go:cgo_import_dynamic __stack_chk_guard __stack_chk_guard ""
+//go:cgo_import_dynamic _dyld_get_image_header _dyld_get_image_header ""
+//go:cgo_import_dynamic _dyld_get_image_name _dyld_get_image_name ""
+//go:cgo_import_dynamic _dyld_get_image_vmaddr_slide _dyld_get_image_vmaddr_slide ""
+//go:cgo_import_dynamic _dyld_get_shared_cache_range _dyld_get_shared_cache_range ""
+//go:cgo_import_dynamic _dyld_get_shared_cache_uuid _dyld_get_shared_cache_uuid ""
+//go:cgo_import_dynamic _dyld_image_count _dyld_image_count ""
+//go:cgo_import_dynamic _exit _exit ""
+//go:cgo_import_dynamic abort abort ""
+//go:cgo_import_dynamic arc4random_buf arc4random_buf ""
+//go:cgo_import_dynamic close close ""
+//go:cgo_import_dynamic dlsym dlsym ""
+//go:cgo_import_dynamic dup dup ""
+//go:cgo_import_dynamic dup2 dup2 ""
+//go:cgo_import_dynamic dyld_shared_cache_iterate_text dyld_shared_cache_iterate_text ""
+//go:cgo_import_dynamic execve execve ""
+//go:cgo_import_dynamic exit exit ""
+//go:cgo_import_dynamic fstat$INODE64 fstat$INODE64 ""
+//go:cgo_import_dynamic ftruncate ftruncate ""
+//go:cgo_import_dynamic getpid getpid ""
+//go:cgo_import_dynamic getrlimit getrlimit ""
+//go:cgo_import_dynamic gettimeofday gettimeofday ""
+//go:cgo_import_dynamic getuid getuid ""
+//go:cgo_import_dynamic grantpt grantpt ""
+//go:cgo_import_dynamic ioctl ioctl ""
+//go:cgo_import_dynamic isatty isatty ""
+//go:cgo_import_dynamic lstat$INODE64 lstat$INODE64 ""
+//go:cgo_import_dynamic mach_absolute_time mach_absolute_time ""
+//go:cgo_import_dynamic mach_task_self_ mach_task_self_ ""
+//go:cgo_import_dynamic mach_timebase_info mach_timebase_info ""
+//go:cgo_import_dynamic mach_vm_region_recurse mach_vm_region_recurse ""
+//go:cgo_import_dynamic madvise madvise ""
+//go:cgo_import_dynamic malloc_num_zones malloc_num_zones ""
+//go:cgo_import_dynamic malloc_zones malloc_zones ""
+//go:cgo_import_dynamic memcpy memcpy ""
+//go:cgo_import_dynamic memset_pattern16 memset_pattern16 ""
+//go:cgo_import_dynamic mkdir mkdir ""
+//go:cgo_import_dynamic mprotect mprotect ""
+//go:cgo_import_dynamic open open ""
+//go:cgo_import_dynamic pipe pipe ""
+//go:cgo_import_dynamic posix_openpt posix_openpt ""
+//go:cgo_import_dynamic posix_spawn posix_spawn ""
+//go:cgo_import_dynamic posix_spawn_file_actions_addclose posix_spawn_file_actions_addclose ""
+//go:cgo_import_dynamic posix_spawn_file_actions_adddup2 posix_spawn_file_actions_adddup2 ""
+//go:cgo_import_dynamic posix_spawn_file_actions_destroy posix_spawn_file_actions_destroy ""
+//go:cgo_import_dynamic posix_spawn_file_actions_init posix_spawn_file_actions_init ""
+//go:cgo_import_dynamic posix_spawnattr_destroy posix_spawnattr_destroy ""
+//go:cgo_import_dynamic posix_spawnattr_init posix_spawnattr_init ""
+//go:cgo_import_dynamic posix_spawnattr_setflags posix_spawnattr_setflags ""
+//go:cgo_import_dynamic pthread_attr_getstack pthread_attr_getstack ""
+//go:cgo_import_dynamic pthread_create pthread_create ""
+//go:cgo_import_dynamic pthread_get_stackaddr_np pthread_get_stackaddr_np ""
+//go:cgo_import_dynamic pthread_get_stacksize_np pthread_get_stacksize_np ""
+//go:cgo_import_dynamic pthread_getspecific pthread_getspecific ""
+//go:cgo_import_dynamic pthread_join pthread_join ""
+//go:cgo_import_dynamic pthread_self pthread_self ""
+//go:cgo_import_dynamic pthread_sigmask pthread_sigmask ""
+//go:cgo_import_dynamic pthread_threadid_np pthread_threadid_np ""
+//go:cgo_import_dynamic read read ""
+//go:cgo_import_dynamic readlink readlink ""
+//go:cgo_import_dynamic realpath$DARWIN_EXTSN realpath$DARWIN_EXTSN ""
+//go:cgo_import_dynamic rename rename ""
+//go:cgo_import_dynamic sched_yield sched_yield ""
+//go:cgo_import_dynamic setrlimit setrlimit ""
+//go:cgo_import_dynamic sigaction sigaction ""
+//go:cgo_import_dynamic stat$INODE64 stat$INODE64 ""
+//go:cgo_import_dynamic sysconf sysconf ""
+//go:cgo_import_dynamic sysctl sysctl ""
+//go:cgo_import_dynamic sysctlbyname sysctlbyname ""
+//go:cgo_import_dynamic task_info task_info ""
+//go:cgo_import_dynamic tcgetattr tcgetattr ""
+//go:cgo_import_dynamic tcsetattr tcsetattr ""
+//go:cgo_import_dynamic unlink unlink ""
+//go:cgo_import_dynamic unlockpt unlockpt ""
+//go:cgo_import_dynamic usleep usleep ""
+//go:cgo_import_dynamic vm_region_64 vm_region_64 ""
+//go:cgo_import_dynamic vm_region_recurse_64 vm_region_recurse_64 ""
+//go:cgo_import_dynamic waitpid waitpid ""
+//go:cgo_import_dynamic write write ""
diff --git a/src/runtime/race/race_darwin_arm64.go b/src/runtime/race/race_darwin_arm64.go
new file mode 100644
index 00000000000..fe8584c3224
--- /dev/null
+++ b/src/runtime/race/race_darwin_arm64.go
@@ -0,0 +1,95 @@
+// Copyright 2022 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// Code generated by mkcgo.sh. DO NOT EDIT.
+
+//go:build race
+
+package race
+
+//go:cgo_import_dynamic _NSGetArgv _NSGetArgv ""
+//go:cgo_import_dynamic _NSGetEnviron _NSGetEnviron ""
+//go:cgo_import_dynamic _NSGetExecutablePath _NSGetExecutablePath ""
+//go:cgo_import_dynamic __error __error ""
+//go:cgo_import_dynamic __fork __fork ""
+//go:cgo_import_dynamic __mmap __mmap ""
+//go:cgo_import_dynamic __munmap __munmap ""
+//go:cgo_import_dynamic __stack_chk_fail __stack_chk_fail ""
+//go:cgo_import_dynamic __stack_chk_guard __stack_chk_guard ""
+//go:cgo_import_dynamic _dyld_get_image_header _dyld_get_image_header ""
+//go:cgo_import_dynamic _dyld_get_image_name _dyld_get_image_name ""
+//go:cgo_import_dynamic _dyld_get_image_vmaddr_slide _dyld_get_image_vmaddr_slide ""
+//go:cgo_import_dynamic _dyld_image_count _dyld_image_count ""
+//go:cgo_import_dynamic _exit _exit ""
+//go:cgo_import_dynamic abort abort ""
+//go:cgo_import_dynamic arc4random_buf arc4random_buf ""
+//go:cgo_import_dynamic bzero bzero ""
+//go:cgo_import_dynamic close close ""
+//go:cgo_import_dynamic dlsym dlsym ""
+//go:cgo_import_dynamic dup dup ""
+//go:cgo_import_dynamic dup2 dup2 ""
+//go:cgo_import_dynamic execve execve ""
+//go:cgo_import_dynamic exit exit ""
+//go:cgo_import_dynamic fstat fstat ""
+//go:cgo_import_dynamic ftruncate ftruncate ""
+//go:cgo_import_dynamic getpid getpid ""
+//go:cgo_import_dynamic getrlimit getrlimit ""
+//go:cgo_import_dynamic gettimeofday gettimeofday ""
+//go:cgo_import_dynamic getuid getuid ""
+//go:cgo_import_dynamic grantpt grantpt ""
+//go:cgo_import_dynamic ioctl ioctl ""
+//go:cgo_import_dynamic isatty isatty ""
+//go:cgo_import_dynamic lstat lstat ""
+//go:cgo_import_dynamic mach_absolute_time mach_absolute_time ""
+//go:cgo_import_dynamic mach_task_self_ mach_task_self_ ""
+//go:cgo_import_dynamic mach_timebase_info mach_timebase_info ""
+//go:cgo_import_dynamic mach_vm_region_recurse mach_vm_region_recurse ""
+//go:cgo_import_dynamic madvise madvise ""
+//go:cgo_import_dynamic malloc_num_zones malloc_num_zones ""
+//go:cgo_import_dynamic malloc_zones malloc_zones ""
+//go:cgo_import_dynamic memcpy memcpy ""
+//go:cgo_import_dynamic memset_pattern16 memset_pattern16 ""
+//go:cgo_import_dynamic mkdir mkdir ""
+//go:cgo_import_dynamic mprotect mprotect ""
+//go:cgo_import_dynamic open open ""
+//go:cgo_import_dynamic pipe pipe ""
+//go:cgo_import_dynamic posix_openpt posix_openpt ""
+//go:cgo_import_dynamic posix_spawn posix_spawn ""
+//go:cgo_import_dynamic posix_spawn_file_actions_addclose posix_spawn_file_actions_addclose ""
+//go:cgo_import_dynamic posix_spawn_file_actions_adddup2 posix_spawn_file_actions_adddup2 ""
+//go:cgo_import_dynamic posix_spawn_file_actions_destroy posix_spawn_file_actions_destroy ""
+//go:cgo_import_dynamic posix_spawn_file_actions_init posix_spawn_file_actions_init ""
+//go:cgo_import_dynamic posix_spawnattr_destroy posix_spawnattr_destroy ""
+//go:cgo_import_dynamic posix_spawnattr_init posix_spawnattr_init ""
+//go:cgo_import_dynamic posix_spawnattr_setflags posix_spawnattr_setflags ""
+//go:cgo_import_dynamic pthread_attr_getstack pthread_attr_getstack ""
+//go:cgo_import_dynamic pthread_create pthread_create ""
+//go:cgo_import_dynamic pthread_get_stackaddr_np pthread_get_stackaddr_np ""
+//go:cgo_import_dynamic pthread_get_stacksize_np pthread_get_stacksize_np ""
+//go:cgo_import_dynamic pthread_getspecific pthread_getspecific ""
+//go:cgo_import_dynamic pthread_join pthread_join ""
+//go:cgo_import_dynamic pthread_self pthread_self ""
+//go:cgo_import_dynamic pthread_sigmask pthread_sigmask ""
+//go:cgo_import_dynamic pthread_threadid_np pthread_threadid_np ""
+//go:cgo_import_dynamic read read ""
+//go:cgo_import_dynamic readlink readlink ""
+//go:cgo_import_dynamic realpath$DARWIN_EXTSN realpath$DARWIN_EXTSN ""
+//go:cgo_import_dynamic rename rename ""
+//go:cgo_import_dynamic sched_yield sched_yield ""
+//go:cgo_import_dynamic setrlimit setrlimit ""
+//go:cgo_import_dynamic sigaction sigaction ""
+//go:cgo_import_dynamic stat stat ""
+//go:cgo_import_dynamic sysconf sysconf ""
+//go:cgo_import_dynamic sysctl sysctl ""
+//go:cgo_import_dynamic sysctlbyname sysctlbyname ""
+//go:cgo_import_dynamic task_info task_info ""
+//go:cgo_import_dynamic tcgetattr tcgetattr ""
+//go:cgo_import_dynamic tcsetattr tcsetattr ""
+//go:cgo_import_dynamic unlink unlink ""
+//go:cgo_import_dynamic unlockpt unlockpt ""
+//go:cgo_import_dynamic usleep usleep ""
+//go:cgo_import_dynamic vm_region_64 vm_region_64 ""
+//go:cgo_import_dynamic vm_region_recurse_64 vm_region_recurse_64 ""
+//go:cgo_import_dynamic waitpid waitpid ""
+//go:cgo_import_dynamic write write ""