diff --git a/src/runtime/os_openbsd_libc.go b/src/runtime/os_openbsd_libc.go
index 8150753796b..0a342e55339 100644
--- a/src/runtime/os_openbsd_libc.go
+++ b/src/runtime/os_openbsd_libc.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build openbsd && !mips64
+// +build openbsd,!mips64
 
 package runtime
 
diff --git a/src/runtime/os_openbsd_syscall.go b/src/runtime/os_openbsd_syscall.go
index 94e851cde8d..3cdcb6c707b 100644
--- a/src/runtime/os_openbsd_syscall.go
+++ b/src/runtime/os_openbsd_syscall.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build openbsd && !386 && openbsd && !amd64 && openbsd && !arm && openbsd && !arm64
-// +build openbsd,!386,openbsd,!amd64,openbsd,!arm,openbsd,!arm64
+//go:build openbsd && mips64
+// +build openbsd,mips64
 
 package runtime
 
diff --git a/src/runtime/os_openbsd_syscall1.go b/src/runtime/os_openbsd_syscall1.go
index f8f666890aa..c20ee8300e3 100644
--- a/src/runtime/os_openbsd_syscall1.go
+++ b/src/runtime/os_openbsd_syscall1.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build openbsd && !386 && !amd64 && !arm && !arm64
-// +build openbsd,!386,!amd64,!arm,!arm64
+//go:build openbsd && mips64
+// +build openbsd,mips64
 
 package runtime
 
diff --git a/src/runtime/os_openbsd_syscall2.go b/src/runtime/os_openbsd_syscall2.go
index 84543acec4a..af1997131fe 100644
--- a/src/runtime/os_openbsd_syscall2.go
+++ b/src/runtime/os_openbsd_syscall2.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build openbsd && !386 && !amd64 && !arm && !arm64
-// +build openbsd,!386,!amd64,!arm,!arm64
+//go:build openbsd && mips64
+// +build openbsd,mips64
 
 package runtime
 
diff --git a/src/runtime/sys_libc.go b/src/runtime/sys_libc.go
index 346b1ab2850..b1a9f8b5365 100644
--- a/src/runtime/sys_libc.go
+++ b/src/runtime/sys_libc.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build darwin || (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build darwin openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build darwin || (openbsd && !mips64)
+// +build darwin openbsd,!mips64
 
 package runtime
 
diff --git a/src/runtime/sys_openbsd.go b/src/runtime/sys_openbsd.go
index 89203bf85f4..ab3149558b3 100644
--- a/src/runtime/sys_openbsd.go
+++ b/src/runtime/sys_openbsd.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build openbsd && !mips64
+// +build openbsd,!mips64
 
 package runtime
 
diff --git a/src/runtime/sys_openbsd1.go b/src/runtime/sys_openbsd1.go
index 1af48539faa..6f9ad356d44 100644
--- a/src/runtime/sys_openbsd1.go
+++ b/src/runtime/sys_openbsd1.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build openbsd && !mips64
+// +build openbsd,!mips64
 
 package runtime
 
diff --git a/src/runtime/sys_openbsd2.go b/src/runtime/sys_openbsd2.go
index 2d53f67a616..cd1a4e879fb 100644
--- a/src/runtime/sys_openbsd2.go
+++ b/src/runtime/sys_openbsd2.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build openbsd && !mips64
+// +build openbsd,!mips64
 
 package runtime
 
diff --git a/src/runtime/sys_openbsd3.go b/src/runtime/sys_openbsd3.go
index 4ef0bdcf77f..8d77a4b216e 100644
--- a/src/runtime/sys_openbsd3.go
+++ b/src/runtime/sys_openbsd3.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build openbsd && !mips64
+// +build openbsd,!mips64
 
 package runtime
 
diff --git a/src/syscall/exec_bsd.go b/src/syscall/exec_bsd.go
index 569dd675ed2..709066e809b 100644
--- a/src/syscall/exec_bsd.go
+++ b/src/syscall/exec_bsd.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build dragonfly || freebsd || netbsd || (openbsd && !386 && !amd64 && !arm && !arm64)
-// +build dragonfly freebsd netbsd openbsd,!386,!amd64,!arm,!arm64
+//go:build dragonfly || freebsd || netbsd || (openbsd && mips64)
+// +build dragonfly freebsd netbsd openbsd,mips64
 
 package syscall
 
diff --git a/src/syscall/exec_libc2.go b/src/syscall/exec_libc2.go
index 7442d59affc..b999754c2e8 100644
--- a/src/syscall/exec_libc2.go
+++ b/src/syscall/exec_libc2.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build darwin || (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build darwin openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build darwin || (openbsd && !mips64)
+// +build darwin openbsd,!mips64
 
 package syscall
 
diff --git a/src/syscall/syscall_openbsd1.go b/src/syscall/syscall_openbsd1.go
index 450f3848319..15870ce1ee1 100644
--- a/src/syscall/syscall_openbsd1.go
+++ b/src/syscall/syscall_openbsd1.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build openbsd && !386 && !amd64 && !arm && !arm64
-// +build openbsd,!386,!amd64,!arm,!arm64
+//go:build openbsd && mips64
+// +build openbsd,mips64
 
 package syscall
 
diff --git a/src/syscall/syscall_openbsd_libc.go b/src/syscall/syscall_openbsd_libc.go
index 2390912b0f5..e67ee4e571c 100644
--- a/src/syscall/syscall_openbsd_libc.go
+++ b/src/syscall/syscall_openbsd_libc.go
@@ -2,8 +2,8 @@
 // Use of this source code is governed by a BSD-style
 // license that can be found in the LICENSE file.
 
-//go:build (openbsd && 386) || (openbsd && amd64) || (openbsd && arm) || (openbsd && arm64)
-// +build openbsd,386 openbsd,amd64 openbsd,arm openbsd,arm64
+//go:build openbsd && !mips64
+// +build openbsd,!mips64
 
 package syscall