diff --git a/src/cmd/compile/internal/types/identity.go b/src/cmd/compile/internal/types/identity.go
index 89343b8419c..f99e50a1c38 100644
--- a/src/cmd/compile/internal/types/identity.go
+++ b/src/cmd/compile/internal/types/identity.go
@@ -59,7 +59,8 @@ func identical(t1, t2 *Type, flags int, assumedEqual map[typePair]struct{}) bool
 		case TINT32:
 			return (t1 == Types[TINT32] || t1 == RuneType) && (t2 == Types[TINT32] || t2 == RuneType)
 		case TINTER:
-			return (t1 == Types[TINTER] || t1 == AnyType) && (t2 == Types[TINTER] || t2 == AnyType)
+			// Make sure named any type matches any empty interface.
+			return t1 == AnyType && t2.IsEmptyInterface() || t2 == AnyType && t1.IsEmptyInterface()
 		default:
 			return false
 		}
diff --git a/src/cmd/compile/internal/types/type.go b/src/cmd/compile/internal/types/type.go
index b1194fa1962..7d22e2da234 100644
--- a/src/cmd/compile/internal/types/type.go
+++ b/src/cmd/compile/internal/types/type.go
@@ -1211,7 +1211,8 @@ func (t *Type) cmp(x *Type) Cmp {
 			}
 
 		case TINTER:
-			if (t == Types[AnyType.kind] || t == AnyType) && (x == Types[AnyType.kind] || x == AnyType) {
+			// Make sure named any type matches any empty interface.
+			if t == AnyType && x.IsEmptyInterface() || x == AnyType && t.IsEmptyInterface() {
 				return CMPeq
 			}
 		}
diff --git a/test/typeparam/issue49875.go b/test/typeparam/issue49875.go
new file mode 100644
index 00000000000..aece7deab1d
--- /dev/null
+++ b/test/typeparam/issue49875.go
@@ -0,0 +1,14 @@
+// compile -G=3
+
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+package p
+
+func f(args ...interface{}) {}
+
+func g() {
+	var args []any
+	f(args...)
+}